Neurostatus Systems AG


PLEASE NOTE: Since the beginning of August 2016 all Neurostatus products and services are operated and maintained by the Department of Neurology at the University Hospital Basel UHBS. Contact the UHBS also for a Licence to capture and validate electronic Neurostatus/EDSS examination data.


The Neurostatus/EDSS scale is the widely accepted primary endpoint of most clinical trials in Multiple Sclerosis. The products and services are developed in collaboration with the scientific experts of the MS team at the University Hospital Basel (Prof. L. Kappos) and cover the whole process from training and certification and Neurostatus/EDSS raters to electronic data capture, data management and scientific review within clinical trials.


The (E)DSS was initially introduced in 1955 as the Disability Status Scale, a 10-step overall neurological disability rating scale. It was subsequently extended in 1983 by the introduction of half steps, leading to a total of 20 steps ranging from 0 to 10, separated by half-point increments (Expanded Disability Status Scale).

Since the 1982 Prof. L. Kappos was involved in the planning and conducting of numerous clinical MS trial and subsequently improved and standardized the EDSS scale (references), which became the Neurostatus, consisting of the Neurostatus Definitions and Scoring Sheet.

In parallel Neurostatus Systems and it's predecessor companies developed various training and certification programs in collaboration with the Prof. L. Kappos' MS team at the University Hospital Basel. All started with training videos in 1994, continued with a training CD/DVD Rom (1998/2005) and lead to the online certification platform Neurostatus e-Test in 2003.

In 2007 the development of the Neurostatus Algorithm, a digitized version of the complete Neurostatus Definitions, began and was finally validated and implemented in 2011. The complete Neurostatus e-Scoring system, including mobile electronic data capture and data management was introduced in 2013.

Neurostatus/EDSS has become a key endpoint of most phase III clinical trials in Multiple Sclerosis and is accepted by health authorities as a basis for label claims on disability.


The EDSS is based on a standardised neurological examination, but focuses on the symptoms that occur frequently in MS.

Assessment of the seven Functional Systems (FS: visual, brainstem, pyramidal, cerebellar, sensory, bowel & bladder and cerebral) is based on a standardised neurological examination.

Based on the FS scores and on the assessment of the ambulation, the EDSS step is determined. The range of the EDSS includes 20 half steps from 0 to 10, with EDSS step 0 corresponding to a completely normal examination and EDSS step 10 to death due to MS. For EDSS ratings between 0 and 4, the scale relies mainly on the scores of the individual FS. For ratings over 4, the EDSS is primarily determined by the ability and range of walking.


Neurostatus products are used worldwide:

  • Approx. 70 ongoing MS and NMO studies use Neurostatus e-Test
  • 2 studies use Neurostatus e-Scoring since 2013
  • 3 Studies e-Scoring Algorithm since 2011
  • More than 130 studies use Neurostatus e-Test Qualification since 2003
  • More than 10’000 Neurologists have active accounts on
  • More than 25’000 active e-Test Qualifications
  • Approx. 80 new registrations monthly on
  • Approx. 10'000 Training DVD ROMs delivered
Neurostatus Systems AG

Legal note

Version 1.1 / 28-NOV-2013


Access to and use of Neurostatus Products and Services (, Neurostatus e-Test, Neurostatus e-Scoring, Neurostatus Training, Neurostatus Documents) are provided by the Neurostatus Systems AG (following: PROVIDER) and is subject to the following terms:

1 By using you agree to be legally bound by these terms, which shall take effect immediately on your first use of If you do not agree to be legally bound by all the following terms please do not access and/or use

2 The PROVIDER may change these terms at any time by posting changes online. Please review these terms regularly to ensure you are aware of any changes made by the PROVIDER. Your continued use of after changes are posted means you agree to be legally bound by these terms as updated and/or amended.


3 Transmission of Personal Data to Third Parties: Data collected during registration and from visits to the website and stored on log files are transmitted exclusively to the study personnel of the studies published on We do not transmit data for other commercial or non-commercial purposes.

4 Links to External Websites: Our website contains links to external websites. We have no control over whether the operators of these linked websites comply with data protection laws.


5 One (1) single Neurostatus account per User: Holders of a personal Neurostatus account on are not allowed to hold other personal accounts with the same or similar names. If you notice (or suspect) the existence of additional accounts, issuing from earlier activities on, please contact Neurostatus Support in order to merge these accounts.

Whoever intentionally opens several personal e-Test accounts with similar names on, risks non-recognition of e-Tests and EDSS certificates connected to these accounts and cancellation of said accounts.

6 Password usage (Regulatory requirements)

Storage of passwords either digitally or physically is not permitted. Auto-fil functionality of the Internet browser must not be used.
Passwords are for individual use only and must be kept confidential. Sharing of passwords is not permitted.
After Login failure a delay for new login is implemented (increasing time after every failed login)

7 Copy rights and Intellectual property: You may not copy, reproduce, republish, download, post, broadcast, transmit, make available to the public, or otherwise use content in any way except for the intended use as a participant in one or more clinical trials that are licensed to use the content of or being licensed as an 'Individual User'.

You also agree not to adapt, alter or create a derivative work from any content except for your own personal, non-commercial use. Any other use of content requires the prior written permission of the PROVIDER.

The names, images and logos identifying the PROVIDER or third parties and their products and services are subject to copyright, design rights and trademarks of the PROVIDER, and/or third parties. Nothing contained in these terms shall be construed as conferring by implication, estoppel or otherwise any licence or right to use any trademark, patent, design right or copyright of the PROVIDER, or any other third party.


Copyright (Right of Authorship) protected documents (Neurostatus Scoring Sheet, Neurostatus Definitions) may be downloaded by:
Participants licensed to use in one or more clinical studies, licensed for Neurostatus; or Holders of an "Individual User" license; or Administrators/Monitors/Study personnel licensed to administer Neurostatus for one or more clinical studies. 

8 Copyright (Right of Authorship) protected documents (Neurostatus Scoring Sheet, Neurostatus Definitions) which are free to download on, must be used exclusively and under the Proviso of Clause 7 for patient examinations in clinical studies, licensed for

Holder of the Copyright (Right of Authorship) of the documents mentioned above is Prof. Dr. L. Kappos, Chair Neurology, University Hospital Basel.

The following rules and conditions apply to the reproduction of the documents mentioned above:
Single copies on commercial copy-machines are allowed for Study Centers. 
It is not allowed to reproduce these documents in commercial printing shops, copy centers, or other institutions offering a commercial copy service, without the express permission of the PROVIDER. 

The PROVIDER offers his own copy order service on (Neurostatus Scoring).

Translations of these documents into languages other than the existing English and German versions (protected by Copyright resp. Right of Authorship) are allowed under the following conditions:
Previous, explicit and written permission by Prof. L. Kappos
Translations must be authorized by Prof. L. Kappos, explicitly and in writing
Authorized Translations will be placed explicitly under the Copyright of Prof. Dr. L. Kappos, Neurological-Neurosurgical Clinic University Hospital, Basel. 

9 You agree to use only for lawful purposes, and in a way that does not infringe the rights of, restrict or inhibit anyone else's use of Prohibited behaviour includes harassing or causing distress or inconvenience to any person, or disrupting the normal flow of dialogue within 


10 content, including the information, names, images, pictures, logos and icons regarding or relating to the PROVIDER (or to third parties owning sublicenses to use Neurostatus services or products), its products and services (or to third party products and services), is provided "AS IS" and on an "IS AVAILABLE" basis without any representations or any kind of warranty made (whether express or implied by law) to the extent permitted by law, including the implied warranties of satisfactory quality, fitness for a particular purpose, non-infringement, compatibility, security and accuracy. 

11 Under no circumstances will the PROVIDER (or third parties owning sublicenses to use Neurostatus services or products) be liable for any of the following losses or damage (whether such losses were foreseen, foreseeable, known or otherwise): (a) loss of data; (b) loss of revenue or anticipated profits; (c) loss of business; (d) loss of opportunity; (e) loss of goodwill or injury to reputation; (f) losses suffered by third parties; or (g) any indirect, consequential, special or exemplary damages arising from the use of regardless of the form of action. 

12 The PROVIDER does not warrant that functions contained in content will be uninterrupted or error free, that defects will be corrected, or that or the server that makes it available are free of viruses or bugs. 


13 Individual customers on purchasing Training media (Neurostatus Training DVD-ROM, Neurostatus Scoring Documents) by online payment have the right to return damaged products to the PROVIDER, if it is evident that the PROVIDER is responsible for respective damage. The PROVIDER will then replace the damaged product without charging additional costs. 

14 Individual Users on purchasing services (Neurostatus e-Test) by online payment have the right to ask for additional e-Test trials, in case of a system failure leading to an unsuccessful qualification attempt after three e-Test trials. This right is granted after three (3) unsuccessful trials. Requests for additional trials must be addressed to the Neurostatus Administration by email (email address available in menu 'contact' on 


15 Where you are invited to submit any contribution to (including any text, photographs, graphics, video or audio) you agree, by submitting your contribution, to grant the PROVIDER a perpetual, royalty-free, non-exclusive, sub-licensable right and license to use, reproduce, modify, adapt, publish, translate, create derivative works from, distribute, perform, play, make available to the public, and exercise all copyright and publicity rights with respect to your contribution worldwide and/or to incorporate your contribution in other works in any media now known or later developed for the full term of any rights that may exist in your contribution, and in accordance with privacy restrictions set out in the PROVIDER's Privacy Policy. If you do not want to grant to the PROVIDER the rights set out above, please do not submit your contribution to 

16 Further to paragraph 3 (Privacy Police), by submitting your contribution to, you: 

a) warrant that your contribution; 
is your own original work; 
is not defamatory; and 
does not infringe any law; and 

b) warrant that your contribution: 
is published under your own name and under no other; 
is published under your own e-mail address and not under the e-mail address of another person; and 

c) that you indemnify the PROVIDER against all legal fees, damages and other expenses that may be incurred by the PROVIDER as a result of your breach of the above warranty 

17 You agree to use Communities (including Message Boards) in accordance with the following Community Rules. These apply across all community sites and services. 


18 Member Names will be locked if they appear to impersonate someone else or are otherwise objectionable 

We reserve the right to reject messages which;  


The PROVIDER welcomes feedback, both positive and negative, about our programs and services; but please make sure your comments are in line with the above House Rules.


19 We advise that you never reveal any personal information about anyone else (for example: telephone number, home address or email address) unless this person knows about and agrees to the release of his/her personal information.


19 You may not submit any defamatory or illegal material of any nature in Community. This includes text, graphics, video, programs or audio.

Contributing material with the intention of committing or promoting an illegal act is strictly prohibited.

You agree to only submit materials which are your own original work. You must not violate, plagiarise, or infringe the rights of third parties including copyright, trade mark, trade secrets, privacy, publicity, personal or proprietary rights.

The views expressed in Community area are those of members of the public and are not necessarily those of the PROVIDER.


20 If there is any conflict between these terms and specific terms appearing elsewhere on then the latter shall prevail.

21 If any of these terms are determined to be illegal, invalid or otherwise unenforceable by reason of the laws of any state or country in which these terms are intended to be effective, then to the extent and within the jurisdiction in which that term is illegal, invalid or unenforceable, it shall be severed and deleted from these terms and the remaining terms shall survive, remain in full force and effect and continue to be binding and enforceable.

22 These terms shall be governed by and interpreted in accordance with the laws of Switzerland. Eventual disputes shall be under the jurisdiction of the Courts of the Canton Basel City, Switzerland. 

Neurostatus Systems AG
Murbacherstrasse 34
4056 Basel, Switzerland